High Quality Manufacturer Hot Sale Top Purity 99% Food industry Grade succinic acid 110-15-6, In Bulk Supply with Fast Delivery.
Description:
Succinic acid is an alpha,omega-dicarboxylic compound formed by formally oxidizing the terminal methyl groups of butane to carboxy groups at both ends. Within biological processes, it functions as an intermediate metabolite in the citric acid cycle. Succinic acid serves various roles, including acting as a nutraceutical, a radiation protective agent, an anti-ulcer medication, a micronutrient, and a foundational metabolite. In chemical terms, it is classified as an alpha,omega-dicarboxylic acid and a C4-dicarboxylic acid. Additionally, succinic acid acts as the conjugate acid of succinate.
Details:
Succinic acid, also known as butanedioic acid, plays a significant role in various biological and metabolic processes as well as in microbial metabolism. Here's a description of succinic acid:
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Dicarboxylic Acid:
Succinic acid is classified as a dicarboxylic acid because it contains two carboxyl (-COOH) functional groups. This molecular structure gives it acidic properties.
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Role in Citric Acid Cycle (TCA Cycle):
The anion of succinic acid, known as succinate, is a crucial component of the citric acid cycle, also known as the tricarboxylic acid (TCA) cycle. This cycle is a fundamental metabolic pathway in aerobic respiration.
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Electron Donation to Electron Transfer Chain:
Succinate is capable of donating electrons to the electron transport chain, a process that is essential for the production of cellular energy in the form of ATP (adenosine triphosphate).
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Succinate Dehydrogenase (SDH):
Succinic acid dehydrogenase (SDH) is an enzyme that plays a pivotal role in mitochondrial function. SDH is a part of both the respiratory chain and the Krebs cycle. It contains a covalently attached FAD (flavin adenine dinucleotide) prosthetic group.
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Substrates and Regulators:
SDH can bind to several different enzyme substrates, including succinate and fumarate, as well as physiological regulators like oxaloacetate and ATP.
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Involvement in the Krebs Cycle:
The oxidation of succinate by SDH is a critical step in the Krebs cycle, leading to the breakdown of acetyl-CoA and the generation of energy.
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Transport into Mitochondrial Matrix:
Succinate can be transported into the mitochondrial matrix through the n-butylmalonate- or phenylsuccinate-sensitive dicarboxylate carrier. This exchange can occur with inorganic phosphate or other organic acids like malate.
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Association with Diseases:
Mutations in the genes encoding the subunits of mitochondrial succinate dehydrogenase have been associated with various clinical conditions, including Huntington's disease.
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Oncometabolite:
Succinic acid has been identified as an oncometabolite, meaning it can contribute to the development of cancer. High levels of succinic acid are found in tumors and the biofluids surrounding them. It is believed to inhibit prolyl hydroxylase-containing enzymes, which play a role in regulating the response to hypoxia (low oxygen levels).
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Microbial Metabolite:
Succinic acid is also produced by various microbial species, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Enterobacter, Acinetobacter, Proteus mirabilis, Citrobacter frundii, and Enterococcus faecalis.
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Presence in Other Microbes:
In addition to the mentioned microbes, succinic acid is found in Actinobacillus, Anaerobiospirillum, Mannheimia, Corynebacterium, and Basfia.
Applications:
succinic acid has diverse applications across industries, ranging from the synthesis of polymers and resins to its role as a food additive and pharmaceutical excipient, making it a versatile and valuable compound in various fields.
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Polymer and Resin Precursor:
Succinic acid plays a crucial role as a precursor in the production of various polymers, resins, and solvents. It is a key ingredient in the synthesis of certain polyesters and alkyd resins. Additionally, it serves as a starting material for the synthesis of 1,4-Butanediol (BDO).
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Automotive and Electronics Industries:
BDO, derived from succinic acid, finds extensive use in industries such as automotive and electronics. It is employed in the manufacture of connectors, insulators, wheel covers, gearshift knobs, and reinforcing beams, contributing to the production of essential components in these sectors.
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Biodegradable Polymers:
Succinic acid serves as a foundational component for the creation of biodegradable polymers. These polymers hold great promise, particularly in tissue engineering applications, as they can break down naturally over time, minimizing environmental impact.
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Succination:
The process of acylation using succinic acid is termed succination. It's noteworthy that oversuccination can occur when multiple succinate molecules add to a substrate, leading to various chemical reactions.
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Food Additive and Dietary Supplement:
Succinic acid has gained recognition as a safe food additive and dietary supplement, endorsed by the U.S. Food and Drug Administration (FDA). It finds use primarily as an acidity regulator in the food and beverage industry. Additionally, it is employed as a flavoring agent, contributing a mildly sour and astringent element to enhance the umami taste experience.
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Pharmaceutical Excipient:
Succinic acid is employed as an excipient in pharmaceutical products. It serves the purpose of controlling acidity in drugs and can also function as a counter ion. Pharmaceutical drugs that involve succinate in their composition include metoprolol succinate, sumatriptan succinate, Doxylamine succinate, and solifenacin succinate.
About us:
Anhui Sunsing Chemicals Co., Ltd., formerly known as Chizhou Sanyuan Chemical Co., Ltd., has evolved into a prominent high-tech enterprise in Anhui, China. It holds a significant position as one of the key manufacturers of Organic Pigments and stands as the largest producer of Succinic Acid in the country.
The company boasts total assets amounting to USD 3,622,943. Its extensive facility spans across 88,000 square meters, with a building area of 22,794 square meters. The dedicated team consists of over 180 staff and workers, including more than 50 specialized technical and administrative personnel, 5 senior engineers, and 26 intermediate technicians. Anhui Sunsing Chemicals Co., Ltd. has achieved ISO9001:2000 Quality authentication system certification and STAR-K authentication.
The company's primary product offerings encompass Pigments Series, Succinic Acid, and related derivatives such as Disodium Succinate, Dikalium Succinate, Calcium Succinate, Diethyl Succinate, and Dimethyl Succinate, along with Fine Anhydrous Calcium Chloride, among others.
