Efficacy of derivatives of 3-hydroxypyridine and succinic acid in diabetic patients with the diabetic foot. A prospective placebo-controlled study was performed to examine the effects of emoxipine, reamberine, and mexidole on the severity of neuropathic and anxiety-depressive symptom clusters, by simultaneously evaluating the parameters of the lipid peroxidation-antioxidative defense protection (LPO-AOD) system in diabetic patients with the diabetic foot.

The 14-day use of all the test drugs was found to cause a significant attenuation of diabetic neuropathy and to abolish concomitant anxiety and depression. The positive clinical effect of emoxipine and reamberine was shown to be associated with the stimulation of AOD and with the limitation of LPO. Mexidole is not inferior to emoxipine and reamberine in its clinical efficacy, but it did not change the parameters of the LPO-AOD system as compared with placebo.