|
A skin-moisture-regulating composition for cosmetic or dermatological preparations, the composition containing succinic acid derivatives corresponding to formula I: R1 O(Cn H2n O)x CO--CHR2 --CHR3 --CO(OCn H2n O)y OR4 (I)wherein R1 is an alkyl, alkenyl, mono-or dihydroxyalkyl or hydroxyalkenyl group containing 6 to 22 carbon atoms, one of R2 and R3 is hydrogen and the other is an alkyl or alkenyl group containing 12 to 22 carbon atoms, n=2 or 3, x and y are average degrees of alkoxylation and have values of 0 to 20 and 1 to 20, respectively, and R4 is hydrogen or a group R1 O--(Cn H2n O)x --CO--CHR2 --CHR3 --CO--, or an alkyl, alkenyl, mono- or dihydroxyalkyl or hydroxyalkenyl group containing 6 to 22 carbon atoms.
This invention relates to new succinic acid(cas:110-15-6) derivatives with a lipid-like structure which are suitable as a skin-moisture-regulating component in cosmetic and dermatological preparations.
The succinic acid(cas:110-15-6) derivatives according to the invention are eminently suitable for use as a skin-moisture-regulating component for the production of cosmetic or therapeutic skin treatment preparations. By virtue of their lipid character, they increase the smoothness and softness of the skin and regulate the transepidermal loss of water without forming a water-impermeable barrier. They prevent the skin from drying out under the effect of climate and surfactants and contribute towards the skin retaining a smooth and youthful appearance.
The succinic acid(cas:110-15-6) derivatives according to the invention are prepared by methods known per se in preparative chemistry from the known alkenyl succinic anhydrides which can be obtained by ene addition of maleic anhydride onto olefins. A corresponding succinic anhydride of general formula II: ##STR1## in which one of the substituents R2 and R3 is hydrogen and the other is an alkenyl group containing 12 to 22 carbon atoms, is reacted with an alcohol of the formula R1 --OH to form the monoester and the monoester is then alkoxylated with (x+y) moles of ethylene oxide (n=2) or propylene oxide (n=3). R1, R2, R3, n, x and y have the same meanings as in formula I. If the substituent R2or R3 is to be an alkyl group, the succinic anhydride corresponding to formula II, the monoester or the alkoxylate may be hydrogenated to saturate the double bonds present.
|
