Succinic acid
Succinic acid
110-15-6
disodium succinate
Phthalocyanine pigment
Compound dyes
Compound green
Composite blue
The Background of Method for purifying succinic acid(cas:110-15-6) from fermentation broth
Release time:2016/8/15 17:05:12

Succinic acid is produced by bringing a succinic acid(cas:110-15-6)-containing liquid containing succinic acid(cas:110-15-6) and cation which is obtained by fermentation or an enzymatic method into contact with an H-type strongly acidic cation-exchange resin in an amount equivalent to or more than the amount of cation other than hydrogen ion contained in the succinic acid(cas:110-15-6)-containing liquid, and precipitating a crystal of succinic acid from the obtained ion-exchange-treated liquid to obtain purified succinic acid(cas:110-15-6).

BACKGROUND ART

In recent years, succinic acid(cas:110-15-6) draws attention as a raw material of biodegradable polymers. Further, succinic acid(cas:110-15-6) is widely used as a raw material of special chemical products as a 4-carbon intermediate. To use succinic acid as a raw material of biodegradable polymers and special chemical products, it is necessary to produce succinic acid(cas:110-15-6) of high purity at a low cost. This is because impurities contained in the raw material succinic acid(cas:110-15-6) may inhibit a reaction for producing a final product from succinic acid or degrade quality of the final product.


Accordingly, in order to produce succinic acid(cas:110-15-6) to be used as a raw material of polymers or special chemical products by fermentation or an enzymatic method, it is necessary to efficiently remove impurities from a fermentation broth or enzymatic reaction mixture containing a large amount of impurities and produce succinic acid at a low cost.


In the production of succinic acid(cas:110-15-6) by fermentation or an enzymatic method, a counter ion is generally added to a medium or an enzymatic reaction solution to maintain optimal pH. Therefore, succinic acid often exists in the form of a salt in a culture broth or an enzymatic reaction mixture in which succinic acid(cas:110-15-6) is accumulated. Therefore, the counter ion added to the fermentation medium or enzymatic reaction solution must be removed in order to produce succinic acid(cas:110-15-6) of high purity. Further, the fermentation broth contains a large amount of impurities such as other organic acids and amino acids, and these impurities also need to be efficiently removed.


As methods for producing succinic acid(cas:110-15-6) of high purity, methods using an ion-exchange resin, methods using a hardly soluble salt of succinic acid(cas:110-15-6), methods utilizing electrodialysis and so forth have been reported so far.

The methods using an ion-exchange resin are roughly classified into methods using an anion-exchange resin and methods using a weakly acidic cation-exchange resin.


As the method using an anion-exchange resin, a method comprising bringing a raw material liquid containing a salt of succinic acid into contact with an anion-exchange resin to allow the resin to adsorb succinic acid(cas:110-15-6) and then eluting succinic acid(cas:110-15-6) with an organic solvent, aqueous ammonia or the like has been reported (refer to Patent documents 1 and 2). In this method, however, an organic solvent or alkali such as ammonia contained in the eluate must be removed and collected, and this makes the process complicated.


Further, a method comprising allowing a cation-exchange resin to adsorb a counter ion for succinic acid(cas:110-15-6) and collecting succinic acid(cas:110-15-6) as a through-flow solution has been reported (refer to Patent document 3). However, this method suffers from a problem that, since the ion-exchange resin to be used is a weakly acidic cation-exchange resin, the counter ion for succinic acid in the raw material liquid are limited to ammonia, and the method cannot be applied to salts of succinic acid with other counter ions.


As a method using a hardly soluble salt of succinic acid, a method comprising adding calcium ion to a raw material liquid containing a salt of succinic acid(cas:110-15-6) and collecting calcium succinate as a precipitate is known (Patent document 4). However, this method suffers from a problem that removal of calcium salt as by-product generated at the time of removal of calcium from the precipitate is complicated.


Patent documents 5 and 6 disclose methods utilizing electrodialysis. However, these methods suffer from a problem that, it is difficult to remove other organic acid (acetic acid) contained in the raw material liquid since it shows the same behavior as succinic acid(cas:110-15-6).


Meanwhile, as a method for collecting an organic acid such as succinic acid from an aqueous solution containing the organic acid, a method of adjusting a concentration of hydrogen ion in the aqueous solution to a level required to bind an anion of organic acid or more by using an H-type ion-exchange resin has been reported (Patent document 7). It is described that, when the concentration of hydrogen ion is adjusted to the level required to bind an anion of organic acid in this method, a concentration higher than the equivalent concentration by 1 to about 10% is preferable. However, it is difficult to substantially completely remove cation contained in a fermentation broth as counter ion for succinic acid even if the concentration of hydrogen ion is adjusted to such a concentration, and therefore a problem arises that purity of succinic acid(cas:110-15-6) decreases.

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