Succinic acid
Succinic acid
110-15-6
disodium succinate
Phthalocyanine pigment
Compound dyes
Compound green
Composite blue
Thio succinic acid(cas:110-15-6) derivatives and the use thereof
Release time:2016/8/2 16:57:58

The present invention relates to compounds of the formula (I) wherein X 1 and X 2 independently represent O, NH or S, R 1 and R 2 are independently selected from the group consisting of a C 1 -C 30 hydrocarbyl group, an amino acid bonded via an amide bond or a peptide bonded via an amide bond each having up to 200 amino acids, the conjugated residue X 1 or X 2 in this case being NH, and hydrogen, both radicals R 1 and R 2 preferably not being H, wherein R 3 is a residue selected from group consisting of —S—R 6 , wherein R 6 is a C 1 -C 30 hydrocarbyl group, at least one of R 1 and R 2 not being H when X 1 and X 2 are oxygen, —S—CH 2 —CH(NH 2 )(COOH) (cysteine-S-yl), a homologue or derivative (e.g. N-acetyl cysteine-S-yl) thereof, a peptide having up to 200 amino acids which contains at least one amino acid radical with a thiol group, preferably a cysteine radical, and is bonded via the thio sulfur, preferably via the cysteine sulfur (peptide-S-yl), coenzyme A which is bonded via a thiol group or fragments thereof, acyl carrier protein bonded via a thiol group, and dihydrolipoic acid bonded via a thiol group, and pharmaceutically acceptable salts thereof. The present invention also relates to the use of these compounds for preparing a drug and drugs containing the same.


The present invention relates to thiosuccinic acid derivatives and the use thereof for preparing a drug as well as drugs containing these derivatives.


This objective is achieved by a number of thiosuccinic acid(cas:110-15-6) derivatives. The applicant has found surprisingly that the effect of such substances is similar to that of fumaric acid derivatives. The inventors assume that this is due to the conversion of the thiosuccinic acid(cas:110-15-6) derivatives to the active fumaric acid derivatives under physiological conditions. In a first aspect, the present invention therefore relates to compounds of the formula

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