Succinic acid
Succinic acid
disodium succinate
Phthalocyanine pigment
Compound dyes
Compound green
Composite blue
Higher increase in succinic acid(cas:110-15-6) production
Release time:2016/7/11 20:45:23

Research at the University of Hamburg, Germany confirms the safe and positive effects of succinic and fumaric acids in cellular metabolism.Dr. Veniamin Khazanov of the RAS' Institute of Pharmacology at the Tomsk Scientific Center says "For aged people, succinic acid has proved to be indispensable. It is capable of restoring the energy balance at the cellular level, which is often upset as the years go by, and helps the patient regain his youthful energy." He says also that it has proven the equal or better of many commercial drugs and is significantly less expensive.

A Dominican Monk, Albert The Great, born in 1193, called Natural Baltic Amber Succinium and stated that it was the most effective of the leading medicines of the time. In order of effectiveness he listed them as Succinium, ocastoreum, mors, camphor, tartarus, and aurum. Amber tinctures were made from beer, wine and water. People found them effective against everything from stomach aches to rheumatism.

These results show that in S. cerevisiae as described increased succinic acid production about 3 times. Additional overexpression of mitochondrial fumarate reductase (FRDm1) from T. brucei further increased succinic acid production levels; overexpression of PCKa, MDH3, FUMR, FRDm1 resulted in production of 2.6 g/L succinic acid(cas:110-15-6), and overexpression of PCKm, MDH3, FUMR and FRDm1 resulted in production of 2.7 g/L succinic acid(cas:110-15-6). Overexpression of delta12NMDH2 in combination with PCKm, FUMR and FRDm1 resulted in production of 2.7 g/L succinic acid(cas:110-15-6), indicating that similar levels of succinic acid were produced using either truncated MDH2 or MDH3. Additional overexpression of glycosomal fumarate reductase (FRDg) from T. brucei resulted in an even higher increase in succinic acid(cas:110-15-6) production levels; overexpression of PCKa, MDH3, FUMR and FRDg resulted in production of 3.9 g/L succinic acid, whereas overexexpression of PCKm, MDH3, FUMR and FRDg resulted in slightly lower production of 3.6 g/L succinic acid.

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