Succinic acid
Succinic acid
110-15-6
disodium succinate
Phthalocyanine pigment
Compound dyes
Compound green
Composite blue
Disodium succinate hexahydrate
Release time:2016/3/18 16:30:26
There is no available information on toxicokinetics and metabolism.
An oral acute toxicity study [OECD TG 401] of disodium succinate hexahydrate showed that this chemical did not cause any changes even at 2,000 mg/kg. The oral LD50 value was considered to be greater than 2,000 mg (equivalent to 1,200 mg of disodium succinate)/kg bw in male and female rats.
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test [OECD TG 422], Crj: CD (SD) IGS rats were given disodium succinate hexahydrate by gavage at 0, 100, 300, or 1,000 mg/kgbw/day. Males were dosed for 52 days from day 14 before mating and females were dosed from day 14 before mating to day 4 of lactation throughout the mating and pregnancy period. Blood urea nitrogen levels were increased in females at 1,000 mg/kg bw/day. Higher levels of urinary protein were found in one and two of the five males at 300 and 1,000 mg/kg bw/day, respectively, whereas no animals with these high levels were found in the control and 100 mg/kg bw/day groups. These findings suggest adverse effects of this compound on the kidney. Therefore, the NOAEL ofdisodium succinate hexahydrate for repeated dose toxicity was considered to be 100 mg (equivalent to 60 mg of disodium succinate)/kg bw/day for male rats and 300 mg (equivalent to 180 mg of disodium succinate)/kgbw/day for female rats.
In a reverse gene mutation assay [OECD TG 471], disodium succinate hexahydrate was not mutagenic in Salmonella typhimurium TA98, TA100, TA1535, and TA1537, and Escherichia coli WP2 uvrA with and without an exogenous metabolic activation. In a chromosomal aberration test [OECD TG 473], disodium succinate hexahydrate did not induce structural chromosomal aberrations or polyploidy with and without an exogenous metabolic activation in cultured Chinese hamster lung (CHL/IU) cells.
There is no data available on the carcinogenicity.
The above-mentioned combined study [OECD TG 422] showed that the reproduction/developmental parameters, i.e.,mating, pregnancy, delivery, lactation, and viability and body weight of pups, were not affected by disodium succinate hexahydrate at up to 1,000 mg/kg bw/day. The NOAEL of disodium succinate hexahydrate for reproduction/developmental toxicity was considered to be 1,000 mg (highest dose tested, equivalent to 600 mg of disodium succinate)/kg bw/day in rats.
There is no available information on eye and skin irritation and sensitization.
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