Succinic Acid News1

Succinic Acid CAS# 110-15-6 quality assurance price

Succinic Acid CAS 110-15-6 manufacturer spot Succinic acid, Succinic acid quality assurance price

Succinic acid is an important "C4 platform compound", which is widely used in food, medicine and agriculture, as a raw material for the synthesis of 1,4-butanediol, tetrahydrofuran, N-methylpyrrolidone and biodegradable biopolymers such as polybutylene glycol succinate. The biosynthesis of 1 molar butanedioic acid will be a promising application. The biosynthesis of 1 mole of succinic acid will fix 1 mole of carbon dioxide, so the production of succinic acid by fermentation with carbon dioxide as raw material can not only reduce the cost of raw materials, but also reduce greenhouse gas emissions.

Succinic acid is also known as succinic acid. The molecular formula HOOCCH2CH2COOH. Succinic acid is found in amber, but also in a wide variety of plants and human and animal succinic acid tissues, such as immature grapes, beets and rhubarb, human blood and muscle, bovine brain, spleen and thyroid gland. Succinic acid is an intermediate in the metabolism of carbohydrates in the body. Succinic acid is widely distributed in the animal and plant kingdoms and was first discovered in 1550 by Agricola during the distillation of amber, hence the name succinic acid. Succinic acid (SA) is an intermediate in the synthesis of many organic substances and an important raw material for the manufacture of drugs, and is widely used in food, medicine and chemical industry. It is widely used in food, medicine, chemical industry and other fields, and with the development of the times, there are new breakthroughs in the application of succinic acid and its extension products.

Succinic acid is colorless crystal; relative density 1.572(25/4℃), melting point 188℃, decompose at 235℃; can be sublimated by distillation under reduced pressure; soluble in water, slightly soluble in ethanol, ether and acetone. As ionic chelating agent, succinic acid is used in the electroplating industry to prevent dissolution and pitting of metals; Succinic acid is a good surfactant, a component of descaling agents, soaps and emulsion breakers; Succinic acid can produce depilatory agents, toothpaste, cleaning agents, efficient wrinkle beauty esters. Succinic acid is also used in lubricants, additives, and elastomers.

Basic information

Chinese name: succinic acid

English name: succinic acid

Chinese name 2: succinic acid

English name 2: amber acid

CAS No.: 110-15-6

Molecular formula: C4H6O4

Molecular weight: 118.09

Physical and chemical properties

Main components: Content: ≥99.0%; sulfate ≤0.02%; heavy metal ≤0.002%; iron ≤ 0.002%; ash ≤ 0.1%.

Appearance and properties: Colorless or white, odorless and acidic prismatic or flaky crystals.

Melting point(℃): 185

Boiling point(℃): 235(decomposition)

Relative density (water=1): 1.57(15℃)

Solubility: soluble in water, ethanol, ether, acetone.

Succinic acid is widely used in pharmaceutical, dye, paper, textile, spice, coating, food, plastic and other industries; currently, the sales volume of industrial grade succinic acid is over 15,000t, largely produced by petrochemical method from butane through cis-butenedianhydride. Only succinic acid for the food market is produced by the fermentation method.

Butanedioic acid produced from butanedioic acid alkyd resin has good flexibilization, elasticity and water resistance, which can be used in the pharmaceutical industry to produce sulfonamides, vitamin A, vitamin B and hemostatic drugs; diphenyl ester of butanedioic acid is an intermediate of dyestuff, and reacts with amino anthraquinone to produce anthraquinone dyestuff; in addition, butanedioic acid also has a wide range of uses in paper manufacturing, textile industry, and can also be used as lubricants, photographic chemicals and It is also used as a raw material for lubricants, photographic chemicals and surfactants. Succinic acid is also used as a food acidifier for flavoring wine, feed, and candy. With sales of more than $400 million per year, it is conceivable that the market for succinic acid is quite large, so the main markets for succinic acid are in the following areas.

? Food industry application areas

Directly applied in food.

1、Acid (chemical) agent ;

2、Buffering agent, neutralizing agent;

3、Japanese sake, fermented soybean paste, soy sauce, cool drinks, sugar products and other flavoring agents.

Synthesize a variety of food additives from other raw materials.

1, emulsifier, dough improver, nutritional supplements;

2、Preparation of berry flavors and as a solvent for fruit-based spices;

3, flavor improver, acidifier, mainly used in the preparation of soy sauce and used in sausage, ham, surimi products, etc;

4、Dried shellac.

? Chemical industry applications

1、Biodegradable plastic (PBS);

2、Dimethyl succinate;

3、Electroplating PH value adjusting agent;

4、Alkyd resin;


6、Varnish viscosity stabilizer;

7、Lubricants and surfactants for photographic chemicals;


? Pharmaceutical industry applications

1、Diuretics, expectorants, vitamin A, vitamin B, sulfonamides, synthesis of hemostatic drugs;

2、Antidote, antitussive agent;

? Other application areas

1、An important organic reagent;

2、A widely used plant growth hormone.

Preparation method

Used in the preparation of pentacyclic compounds. The product is an organic chemical raw material with a wide range of applications. Dosing - electrochemical synthesis - decolorization - cooling crystallization - static system - centrifugal separation - drying - packaging

There are more industrial preparation methods, mainly as follows.

1. Oxidation method

Paraffin wax is deeply oxidized to produce a mixture of various carboxylic acids, and then separated by water distillation and crystallization to obtain succinic acid.

2. Hydrogenation method

Hydrogenation of maleic anhydride or transbutenedioic acid under the action of a catalyst produces succinic acid, which is then separated to obtain the finished product. The catalyst is nickel or precious metal, and the reaction temperature is about 130- 140℃.

3. Acrylic acid carbonyl synthesis method

Acrylic acid and carbon monoxide in the presence of a catalyst to produce butanedioic acid. Not yet industrialized.

4. Electrolytic oxidation method

Phthalic anhydride and sulfuric acid and water in the ratio of 1:0.5:4, electrolysis in a ceramic electrolyzer, can be obtained butanedioic acid. Electrolytic synthesis of raw materials for maleic acid or maleic anhydride, cathode and anode solution with dilute sulfuric acid, separated by a cationic membrane, cathode and anode are generally used lead plate, usually with a plate and frame electrolyzer synthesis.

5. Acetylene method

Acetylene reacts with carbon monoxide and water in the presence of [CO(CO)4] catalyst in acidic medium to obtain succinic acid, reaction temperature 80-250℃, pressure 2.94-49.03MPa.

6. Emerging fermentation method

Compared with traditional chemical methods, microbial fermentation method for succinic acid production has many advantages: competitive production cost; use of renewable agricultural resources, including carbon dioxide, as raw materials, avoiding the dependence on petrochemical raw materials; reduce the pollution of the environment by chemical synthesis process.

Precautions: Less toxic, irritating to eyes, skin and mucous membranes, not toxic to the whole body. This product is flammable and irritating. Less toxic, irritating to eyes, skin and mucous membranes, but not toxic to the whole body.

Environmental hazards: It is hazardous to the environment and can cause pollution to water bodies and the atmosphere.

Flammability hazard: The product is flammable and irritating.

Hazardous characteristics: Flammable when exposed to open flame and high heat. Powder and air can form an explosive mixture, when it reaches a certain concentration, it will explode in contact with a spark. Decomposition by high heat, emitting irritating fumes.

Pharmacological effects

1. Antibacterial effect of succinic acid at a concentration of 2mg/ml has an inhibitory effect on Staphylococcus aureus, Staphylococcus catarrhalis and Bacillus typhi, Pseudomonas aeruginosa, S. dysenteriae.

2. Central inhibitory effect rats, mice, guinea pigs, rabbits, cats and dogs intraperitoneal injection of succinic acid can protect animals against hyperbaric, electroconvulsive and auditory convulsions. The anticonvulsant effect is associated with increased GABA content in the brain. Hot plate method has analgesic effect and synergistic effect with pentobarbital, as well as sedative and hypothermic effect.

3. Anti-ulcer effect on gastric ulcer produced by pyloric ligation in rats, 50mg/kg injected intraperitoneally or orally, anti-ulcer effect due to inhibition of gastric juice secretion and dilatation of gastric muscle.

4. Effects on immune function: Succinic acid was dissolved in saline and pH adjusted to 6.4 by adding NaHCO3 at a concentration of 11.8%. 1mM (118mg)/kg, 2.5mM (295mg)/kg and 5mM (590mg)/kg were injected intraperitoneally into rats and rabbits daily for 7d, once daily. 0.025), but the increase in phagocytosis was not significant. In rabbits, the leukocyte count increased significantly at higher doses, and the phagocytosis rate also increased (P<0.01). In the specific skin reaction test, intraperitoneal injection of succinic acid 5mg/kg for 4 times in 48h or once daily for two weeks, succinic acid inhibited passive and active skin allergic reactions in rabbits and reduced the formation of serum 1gE antibody in animals.

5.Antitoxic effect Succinic acid has obvious protective effect on mice in poisonous cobra, and the rate of protection is similar to the original formula.

Source of ingredients

Succinic acid natural source is the resin of the pine plant buried in the ground for a long time to become amber, etc., in addition to a wide range of plants, animal tissue. Succinic acid is the resin of pine plant, buried in the ground for a long time to make amber, amber contains 7.8% of this product. Angelica sinensis (Oliv.) Diels root of Umbelliferae, Pothos chinensis (Raf.) Merr. of Tennantaceae, Lesspedeza caneata G. Don of Leguminosae, Lo-belia chinen-sis of Erythrinaceae Lour. whole herb, Orchidaceae Sarcardra glabra (Thumb.) Nakai whole herb, Sandalwood spice plant Thesium chinense Turcz. whole herb. Leguminosae Cloverleaf; Umbelliferae Angelicae Root; Tennantaceae Vine Orange; Erythrinaceae Hemipterocarpus; Orchidaceae; Sandalwood and Strawberry. Grapes, etc.

Product Center

Succinic acid (succinic acid) series

Succinic acid, disodium succinate(hexahydrate), disodium succinate(anhydrous), dipotassium succinate, calcium succinate, ammonium succinate, dimethyl succinate, diethyl succinate, diisopropyl succinate;

Phthalocyanine pigment series

Phthalocyanine blue BGS 15:3, Phthalocyanine blue BGS 15:4, Phthalocyanine blue B 15, Phthalocyanine green G 7, Copper phthalocyanine intermediate ≥95%

Product advantages

As the industry benchmark of supply chain service in the field of chemical products, we have senior industry experience and provide market advantageous price, and have won excellent reputation among many customers.

Industry field Strong strength

As the industry standard of supply chain service in the field of chemical products, we have perfected a set of accurate operation system and established long-term stable and reliable cooperation relationship with many famous chemical companies and large refineries.

Full range of products and sufficient inventory

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Professional team Service on paper

We have rich international trade experience and professional talents in the chemical field, professional customer service team "one-to-one" refinement service, to provide accurate quotation and consulting services, for your procurement comprehensive gate-keeping.

High quality products High quality price

Focus on the process of product quality control, adhere to only "genuine"; senior industry experience, to provide market advantageous prices, and won a good reputation among many customers.

About US

Anhui San-Xin Chemical Co., Ltd. is a manufacturer and operator of fine chemicals, including succinic acid, succinic anhydride and their derivatives. Our products include: succinic acid, succinic anhydride, sodium succinate, potassium succinate, butanediimide, dimethyl succinate, diethyl succinate, dibutyl succinate, etc. Our products are sold nationwide and overseas. Its products are sold nationwide and overseas and are widely used in pharmaceuticals, pesticides, dyestuffs, synthetic spices, synthetic resins, plastic additives, food additives, chemical analysis, electroplating and other fields.

The products are widely used and more than 90% of them are exported to more than 20 countries and regions such as USA, UK, Japan, France, Germany, Australia, Middle East, Hong Kong, Taiwan, Macau, etc. The sales network of the products spreads all over China and we have established long-term business relationships with some large and medium-sized enterprises. In 1997, it was recognized as a provincial high-tech product.

Our main products include food preservatives, food flavors and fragrances, food sweeteners, food emulsifiers, food bulking agents, food thickeners, antioxidants, nutritional fortificants, amino acids, vitamins, health care raw materials, pharmaceutical excipients and other products. The company has strict quality control procedures, scientific business management and efficient logistics operation system, which provide a solid guarantee for the customers to get stable, safe and high quality food additives. We strictly implement the requirements of ISO9001:2008 quality management system standard, and on the basis of this, our succinic acid series products have passed STAR-K certification, FDA certification, etc. Our main production and operation products are: succinic acid series products; we also deal with phthalocyanine organic pigment series, iron oxide series, refined anhydrous calcium chloride and other products.

The essence of Qino's corporate culture is "scientific and open, innovative and enterprising, behave honestly and do real work", which is interpreted with different cultural connotation at different times, and will inspire our Qino staff to strive for the pursuit. In today's increasingly competitive market, we will take strict product quality, reasonable transaction price, after-sales service and honest business reputation as the basis, in accordance with the company values of "the best and the most beautiful, mutual benefit and win-win", with a well-qualified, technical, young and competent staff team, in line with " Customer first, service" business philosophy, and the majority of business partners sincere cooperation, common development, and create a better future. For a long time, San-Xin people pursue the corporate philosophy of honesty and trustworthiness, customer first, and the enterprise spirit of dedication, collaboration, pragmatism and innovation, so that you can feel the sincere and satisfactory San-Xin service. Looking ahead, there is a long way to go, we will, as always, strengthen the friendship and cooperation with friends from all walks of life at home and abroad to promote the development of our common cause!

The future, butanedioic acid market development prospects

Succinic acid has a wide range of promising applications in food, pharmaceuticals, surfactants, green solvents, biodegradable plastics and other fields, and the chemical products market for its derivatives has a large potential. The most promising market at present is as the main raw material for the biodegradable plastic polybutylene glycol succinate. At present, the technology of synthesizing PBS biodegradable plastic from succinic acid has been successfully developed and put into mass production in BASF, Mitsubishi, Tsinghua University and Institute of Physical and Chemical Sciences, Chinese Academy of Sciences, etc. Compared with other biodegradable plastics, PBS not only has excellent mechanical properties, but also has reasonable price and high market demand.

In the future, the annual demand of PBS in China will reach more than 3 million tons, based on the production of 1 ton of PBS consuming 0.62 tons of succinic acid, the consumption of 1.8 million tons of succinic acid, and the current annual production capacity of succinic acid in China is far from being able to meet the needs of the market, the market growth of succinic acid is huge. At present, a number of domestic enterprises are actively preparing to start PBS projects, has successfully produced PBS enterprises Anqing and Xing 2009 production capacity of 10,000 tons, ready to follow up on the annual production capacity of 100,000 tons, Xinfu Pharmaceuticals annual production capacity of 3,000 tons, etc.. And with the successful development of PES plastic (organic polymer material obtained by condensation of succinic acid and ethylene glycol) and PHS plastic (organic polymer material obtained by condensation of succinic acid and adipic acid), two new degradable plastics, the demand for succinic acid will increase greatly. However, the traditional method of producing succinic acid which has been using non-renewable strategic resource petroleum products as raw materials has led to high prices and pollution, inhibiting the development potential of succinic acid as an excellent chemical platform product. The foreign production of succinic acid through biofermentation method uses cheap raw materials, and after reasonable process optimization, produces succinic acid products with more tremendous advantages and development potential, and with China's green industry attention, especially under the growing demand for global sustainable solutions, the competitiveness of biodegradable bio-based polybutylene succinate is enhanced, which will make the bio-based butanedioic acid market become bigger and this method will have a huge development potential.

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