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Magical Disodium Succinate
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Release time：2016/3/24 15:19:06
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Disodium succinate is readily biodegradable (64 - 78% of BOD, 100% of HPLC and 100% of TOC were observed after 14 days in a test according to OECD TG301C). The estimated LogPow is less than -0.59. The BCF is estimated to be low according to the low LogPow value.
This chemical degrades by photochemically induced OH radicals in the atmosphere with a half-life of 360 hours. No estimation for the reaction with ozone is possible. The Henry’s Law constant is estimated to be 5.45 x 10-12 atm m3/mol. Vapor pressure is less than 0.015 Pa at 100 °C and is estimated to be 1.16 x 10-5 Pa at 25 °C. The water solubility is more than 100 g/L at 25 °C.
The main target environmental compartment of this chemical is water and, based on fugacity model(Mackay level III), once this chemical is released into the aquatic phase partitioning to other
compartment is unlikely to occur.
In Japan, this chemical is synthesized by hydrogenation of maleic anhydride. Production processes,hydrogenation with hydrogen, neutralization with sodium hydroxide, purification and crystallization, and drying are performed in closed batch systems with remote control and the possibility of worker exposure to this chemical in these processes is very low.
During the packing process of this chemical under local exhaust ventilation, worker exposure through inhalation of dust is possible, since this chemical is non-volatile. The EHEinh for a worker during the packing operation (the duration is 6.5 hours/day) is estimated to be 0.06 mg/kg/day using the EASE model, assuming that this work is performed through direct handling under local exhaust ventilation, and that succinic acid easily aggregates. The EHEder for the worker during the same packing operation is 7.8 mg/kg/day, assuming that dermal contact to both hands is incidental. As the workers wear gloves, goggles, and dust masks during the packing operation, the actual exposure is probably less than these values.No occupational exposure standard value for this chemical was located.
These findings suggest the adverse effects of this compound on the kidney. Therefore, the NOAEL of disodium succinate hexahydrate for repeated dose toxicity was considered to be 100 mg/kg bw/day for male rats and 300 mg/kg bw/day for female rats (100 and 300 mg of disodium succinate hexahydrate are equivalent to 60 and 180 mg of disodium succinate, respectively).
Regarding acute toxicity to daphnids, a 48 h EC0 of 997 mg/L and a 48 h EC50 > 997 mg/L were reported (OECD TG 202, Daphnia magna, static).
All acute toxicity tests (except that using marine species) were conducted in compliance with GLP and the results were estimated based on the mean measured concentrations.
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