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The oral acute toxicity study of disodium succinate
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Release time：2016/3/22 11:58:55
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There is no available information on toxicokinetics and metabolism.
The oral acute toxicity study [OECD TG 401] of disodium succinate hexahydrate showed that this chemical did not cause any changes even at 2,000 mg/kg. The oral LD50 value was considered to be greater than 2,000 mg/kg bw in male and female rats (2,000 mg of disodium succinate hexahydrate is equivalent to 1,200 mg of disodium succinate ). There is no available information on the eye and skin irritation and sensitization.
Males were dosed for 52 days from day 14 before mating and females were dosed from day 14 before mating to day 4 of lactation throughout the mating and pregnancy period. Slight loose stool was observed in four of the 12 males at 1,000 mg/kg bw/day.
No compound-related changes in the body weight, food consumption, hematology, blood coagulation, or histopathological findings were found. The blood urea nitrogen levels were
increased in females at 1,000 mg/kg bw/day. Higher levels (300mg/dL and higher) of urinary protein were found in one and two of the five males at 300 and 1,000 mg/kg bw/day, respectively,whereas no animals with these high levels were found in the control and 100 mg/kg bw/day groups.
These findings suggest the adverse effects of this compound on the kidney. Therefore, the NOAEL of disodium succinate hexahydrate for repeated dose toxicity was considered to be 100 mg/kg bw/day for male rats and 300 mg/kg bw/day for female rats (100 and 300 mg of disodium succinate hexahydrate are equivalent to 60 and 180 mg of disodium succinate, respectively).
Regarding acute toxicity to daphnids, a 48 h EC0 of 997 mg/L and a 48 h EC50 > 997 mg/L were reported (OECD TG 202, Daphnia magna, static).
All acute toxicity tests (except that using marine species) were conducted in compliance with GLP and the results were estimated based on the mean measured concentrations.
Chronic Toxicity Test Results Regarding chronic toxicity to algae, a 72 h NOErC of 998 mg/L and a NOEbC of 998 mg/L (OECD TG 201, Selenastrum capricornutum, open system) were reported. In daphnids, the effect of disodium succinate on reproduction of Daphnia magna (OECD TG 211, semi-static) was investigated. The 21 d EC50 was more than 95.2 mg/L and a 21 d NOEC of 95.2 mg/L were reported (MOE Japan, 2001). For mortality of parent daphnids, the 21 d LC50 was more than 95.2 mg/L. In these toxicity tests, no adverse effects of the chemical on reproduction of daphnids and/or growth of algae were observed at the highest concentrations.
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