Succinic acid
Succinic acid
disodium succinate
Phthalocyanine pigment
Compound dyes
Compound green
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Exploration into disodium succinate
Release time:2016/3/22 11:52:04

One study is available for repeated dose toxicity. This study was conducted according to an OECD combined repeated dose toxicity study with the reproduction/developmental toxicity screening test guideline [TG 422] [MHLW, Japan, 2002] under GLP. This study was identified as a key study because it was well conducted. The details of this study are as follows. 

No deaths were found in any groups. Slight loose stool was observed in one and four males at 100 and 1,000 mg/kg bw/day, respectively, and one female at 1,000 mg/kg bw/day. Salivation was found in one male and one female at 1,000 mg/kg bw/day. There were no effects of this compound on the body weight, food consumption, hematology, or blood coagulation. The blood sodium levels were higher in males at 300 and 1,000 mg/kg bw/day. The blood urea nitrogen levels were increased in females at 1,000 mg/kg bw/day. Higher levels (300 mg/dL and higher) of urinary proteins were found in one and two of the five males at 300 and 1,000 mg/kg bw/day, respectively,whereas no animals with these high levels were found in the control and 100 mg/kg bw/day groups.These findings suggest adverse effects of this compound on the kidney. Increased weight of the adrenal gland was observed in males at 1,000 mg/kg bw/day. No compound-related effects on the histopathological findings were observed. Based on the higher levels of urinary protein in males and blood urea nitrogen in females, the NOAEL of disodium succinate hexahydrate for repeated dose toxicity was considered to be 100 mg/kg bw/day for male rats and 300 mg/kg bw/day for female rats.

Studies in Humans

In vitro bacterial tests
Three studies were reported (Table 3). No positive results were obtained. The study by MHLW,Japan (2002) was identified as a key study because this study was well conducted according to a current protocol [OECD TG 471; Japanese Guideline for Screening Mutagenicity Testing Chemicals (Chemical Substances Control Law of Japan)] under GLP. Disodium succinate hexahydrate was not mutagenic with and without S9 mix in Salmonella typhimurium TA98, TA100,TA1535, and TA1537, and Escherichia coli WP2 uvrA at up to 5,000 μg/plate (5,000 μg of disodium succinate hexahydrate is equivalent to 3,000 μg of disodium succinate).

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